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Growth Factors Involved in Wound Healing:
  
  Epithelial Growth Factor
   
53-amino acid polypeptide chain
Released during platelet degranulation
Stimulate reepithelialization, angiogenesis, and collangenase activity
  Fibroblast Growth Factor
   
Stimulate angiogenesis
Stimulate endothelial cell proliferation
Stimulate collagen synthesis
Stimulate wound contraction
Stimulate matrix synthesis
Stimulate epithelialization
Produces Keratinocyte growth factor
  Platelet Derived Growth Factor
   
Produced by the alpha granules of the platelet
Activates TGF-b
Stimulates neutrophils and macrophages
Stimulates chemotaxis
Stimulates mitogenesis of fibroblasts and smooth muscle cells
Stimulates collagen synthesis and collagenase activity
Stimulates angiogenesis
  Transforming Growth Factor - b
   
Found in the platelet alpha granules
Reverse the inhibition of wound healing caused by glucocorticoids
Stimulates monocytes to secrete FGF, PDGF, Tumor Necrosis Factor-a (TNF-a), and Interleukin-1
Stimulates fibroblast chemotaxis and proliferation
Potent stimulator of collagen synthesis
Decreased dermal scarring
  Transforming Growth Factor - a
   
Variant of Epithelial Growth Factor
Produced by activated platelets, macrophages, and keratinocytes
Stimulates messenchymal, epithelial, and endothelial cell growth
Stimulates endothelial chemotaxis
  Interleukin - 1
   
Stimulates lymphocyte proliferation
Influences collagenase activity
London Perfusion Science, 5 Great College Street, Westminster, London, SW1P 3SJ Tel: 07703 182 420
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